UDP-glucose—hexose-1-phosphate uridylyltransferase explained

UDP-glucose:hexose-1-phosphate uridylyltransferase
Ec Number:	2.7.7.12
Cas Number:	9026-21-5
Go Code:	0008108
Width:	270

In enzymology, an UDP-glucose—hexose-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

UDP-glucose + alpha-D-galactose 1-phosphate

\rightleftharpoons alpha-D-glucose 1-phosphate + UDP-galactose

Thus, the two substrates of this enzyme are UDP-glucose and alpha-D-galactose 1-phosphate, whereas its two products are alpha-D-glucose 1-phosphate and UDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase. Other names in common use include uridyl transferase, hexose-1-phosphate uridylyltransferase, uridyltransferase, and hexose 1-phosphate uridyltransferase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• KALCKAR HM, BRAGANCA B, MUNCH-PETERSEN HM . 1953 . Uridyl transferases and the formation of uridine diphosphogalactose . Nature . 172 . 1038 . 13111247 . 10.1038/1721038a0 . 4388 . 4273742 . free .
• KURAHASHI K, SUGIMURA A . 1960 . Purification and properties of galactose 1-phosphate uridyl transferase from Escherichia coli . J. Biol. Chem. . 235 . 4 . 940 - 6 . 10.1016/S0021-9258(18)69456-6 . free . 14412847 .
• Book: Mayes JS . Hansen RG . Galactose 1-phosphate uridyl transferase . 1966 . Carbohydrate Metabolism . Methods Enzymol. . 9 . 708 - 713 . 10.1016/0076-6879(66)09143-2 . 978-0-12-181809-8 .
• Saito S, Ozutsumi M, Kurahashi K . 1967 . Galactose 1-phosphate uridylyltransferase of Escherichia coli. II Further purification and characterization . J. Biol. Chem. . 242 . 2362 - 8 . 5338129 . 10 . 10.1016/S0021-9258(18)95970-3 . free .
• SMITH EE, MILLS GT . 1955 . The uridyl transferase of mammary gland . Biochim. Biophys. Acta . 18 . 152 . 13260264 . 10.1016/0006-3002(55)90029-9 . 1 .