UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase explained

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
Ec Number:	6.3.2.7
Cas Number:	9023-51-2
Go Code:	0047482

In enzymology, a UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase is an enzyme that catalyzes the chemical reaction

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine

\rightleftharpoons ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

The 3 substrates of this enzyme are ATP, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate, and L-lysine, whereas its 3 products are ADP, phosphate, and UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming). Other names in common use include MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, synthetase, and UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase. This enzyme participates in peptidoglycan biosynthesis.

References

• Ito E, Strominger JL . 1962 . Enzymatic synthesis of the peptide in bacterial uridine nucleotides I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine . J. Biol. Chem. . 237 . 2689 - 2695 .
• van Heijenoort J . Recent advances in the formation of the bacterial peptidoglycan monomer unit . Natural Product Reports . 18 . 5 . 503–19 . October 2001 . 11699883 . 10.1039/a804532a .