UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase explained

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
Ec Number:	6.3.2.37

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase (UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase, D-lysine-adding enzyme) is an enzyme with systematic name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:D-lysine alpha-ligase (ADP-forming).^[1] This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysine

\rightleftharpoons ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine

The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7.

Notes and References

1. Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D . The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity . The Journal of Biological Chemistry . 281 . 23 . 15680–6 . June 2006 . 16595662 . 10.1074/jbc.M506311200 . free .