UDP-N-acetylglucosamine kinase explained

UDP-N-acetylglucosamine kinase
Ec Number:	2.7.1.176

UDP-N-acetylglucosamine kinase (UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase) is an enzyme with systematic name ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetyl-alpha-D-glucosamine

\rightleftharpoons ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate

The phosphorylation of UDP-N-acetyl-D-glucosamine causes the inhibition of enzyme EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

These enzymes are found as part of plasmid-encoded^[3] and chromosomal^[4] bacterial toxin-antitoxin systems.

Notes and References

1. Mutschler H, Gebhardt M, Shoeman RL, Meinhart A . A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis . PLOS Biology . 9 . 3 . e1001033 . March 2011 . 21445328 . 3062530 . 10.1371/journal.pbio.1001033 . free .
2. Rocker A, Meinhart A . A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity . Molecular Microbiology . 97 . 3 . 589–604 . August 2015 . 25943309 . 10.1111/mmi.13051 . free .
3. Zielenkiewicz U, Ceglowski P . The toxin-antitoxin system of the streptococcal plasmid pSM19035 . Journal of Bacteriology . 187 . 17 . 6094–105 . September 2005 . 16109951 . 1196172 . 10.1128/JB.187.17.6094-6105.2005 .
4. Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A . Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae . The Journal of Biological Chemistry . 282 . 27 . 19606–18 . July 2007 . 17488720 . 10.1074/jbc.m701703200 . free . 11858/00-001M-0000-002C-A8AD-E . free .