UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) explained

UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
Ec Number:3.2.1.184

UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) (UDP-Bac2Ac4Ac 2-epimerase, NeuC) is an enzyme with systematic name UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising).[1] [2] This enzyme catalyses the following chemical reaction

UDP-N,N'-diacetylbacillosamine + H2O

\rightleftharpoons

UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose

This enzyme requires Mg2+. It is involved in biosynthesis of legionaminic acid.

Notes and References

  1. Glaze PA, Watson DC, Young NM, Tanner ME . Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila . Biochemistry . 47 . 10 . 3272–82 . March 2008 . 18275154 . 10.1021/bi702364s .
  2. Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM . The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors . Glycobiology . 19 . 7 . 715–25 . July 2009 . 19282391 . 10.1093/glycob/cwp039 . free .

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