UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase explained

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
Ec Number:2.4.1.285

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase (neoK (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons

UDP + 2'''-acetyl-6'''-hydroxyneomycin C

Involved in biosynthesis of the aminoglycoside antibiotic neomycin.

Notes and References

  1. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T . Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis . ChemBioChem . 9 . 6 . 865–9 . April 2008 . 18311744 . 10.1002/cbic.200700717 .

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