UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase explained

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Ec Number:	2.3.1.201

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (WbpD, WlbB) is an enzyme with systematic name acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate

\rightleftharpoons CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid).

Notes and References

1. Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS . Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa . The Journal of Biological Chemistry . 284 . 18 . 11854–62 . May 2009 . 19282284 . 2673254 . 10.1074/jbc.M808583200 . free .
2. Larkin A, Imperiali B . Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1 . Biochemistry . 48 . 23 . 5446–55 . June 2009 . 19348502 . 2694220 . 10.1021/bi900186u .