UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase explained

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
Ec Number:3.6.1.57

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase (PseG, UDP-6-deoxy-AltdiNAc hydrolase, Cj1312) is an enzyme with systematic name UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose hydrolase.[1] [2] This enzyme catalyses the following chemical reaction

UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose + H2O

\rightleftharpoons

2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose + UDP

The enzyme is involved in biosynthesis of pseudaminic acid.

Notes and References

  1. Liu F, Tanner ME . PseG of pseudaminic acid biosynthesis: a UDP-sugar hydrolase as a masked glycosyltransferase . The Journal of Biological Chemistry . 281 . 30 . 20902–9 . July 2006 . 16728396 . 10.1074/jbc.m602972200 . free .
  2. Schoenhofen IC, McNally DJ, Brisson JR, Logan SM . Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction . Glycobiology . 16 . 9 . 8C-14C . September 2006 . 16751642 . 10.1093/glycob/cwl010 . free .

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