UDP-2,3-diacylglucosamine diphosphatase explained

UDP-2,3-diacylglucosamine diphosphatase
Ec Number:	3.6.1.54

UDP-2,3-diacylglucosamine diphosphatase (UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase.^{[1] [2]} This enzyme catalyses the following chemical reaction

UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H₂O

\rightleftharpoons 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate + UMP

The enzyme catalyses a step in the biosynthesis of lipid A.

Notes and References

1. Babinski KJ, Ribeiro AA, Raetz CR . The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis . The Journal of Biological Chemistry . 277 . 29 . 25937–46 . July 2002 . 12000770 . 10.1074/jbc.m204067200 . free .
2. Babinski KJ, Kanjilal SJ, Raetz CR . Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene . The Journal of Biological Chemistry . 277 . 29 . 25947–56 . July 2002 . 12000771 . 10.1074/jbc.m204068200 . free .