UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase explained

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase
Ec Number:	5.1.3.23

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase (UDP-GlcNAc3NAcA 2-epimerase, UDP-alpha-D-GlcNAc3NAcA 2-epimerase, 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase, WbpI, WlbD) is an enzyme with systematic name 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

\rightleftharpoons UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA.

Notes and References

1. Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS . Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens . The Biochemical Journal . 405 . 1 . 123–30 . July 2007 . 17346239 . 1925246 . 10.1042/BJ20070017 .
2. Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens . Westman, E.L. . McNally, D.J. . Rejzek, M. . Miller, W.L. . Kannathasan, V.S. . Preston, A. . Maskell, D.J. . Field, R.A. . Brisson, J.R. . Lam, J.S. . Biochem. J. . 2007 . 405 . 625 . 10.1042/BJ4050625v . free .
3. Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH . Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase . Acta Crystallographica Section D . 57 . Pt 9 . 1310–2 . September 2001 . 11526328 . 10.1107/s0907444901010885 .