UBR2 explained

E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.^[1]

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003).[supplied by OMIM]

Further reading

• Nagase T, Ishikawa K, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Kwon YT, Xia Z, An JY, etal . Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway . Mol. Cell. Biol. . 23 . 22 . 8255–71 . 2003 . 14585983 . 10.1128/MCB.23.22.8255-8271.2003 . 262401 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Yin J, Kwon YT, Varshavsky A, Wang W . RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway . Hum. Mol. Genet. . 13 . 20 . 2421–30 . 2005 . 15317757 . 10.1093/hmg/ddh269 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kwak KS, Zhou X, Solomon V, etal . Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia . Cancer Res. . 64 . 22 . 8193–8 . 2005 . 15548684 . 10.1158/0008-5472.CAN-04-2102 . free .
• Zenker M, Mayerle J, Lerch MM, etal . Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome) . Nat. Genet. . 37 . 12 . 1345–50 . 2006 . 16311597 . 10.1038/ng1681 . 23050042 .
• Matta-Camacho E, Kozlov G, Li F, Gehring K, etal . Structural basis of substrate recognition and specificity in the N-end rule pathway . Nat Struct Mol Biol. 17 . 10 . 1182–7 . 2010 . 20835242 . 10.1038/nsmb.1894. 20961853 .

Notes and References

1. Web site: Entrez Gene: UBR2 ubiquitin protein ligase E3 component n-recognin 2.