Ubiquilin 4 Explained

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.[1] [2] [3] Ubiquilin 4 regulates proteasomal protein degradation.[4]

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.[5]

Notes and References

  1. Web site: Entrez Gene: Ubiquilin 4 . 2013-06-27 .
  2. Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT . Huda Zoghbi. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein . Hum. Mol. Genet. . 9 . 15 . 2305–12 . September 2000 . 11001934 . 10.1093/oxfordjournals.hmg.a018922. free .
  3. Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K . Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences . Biochem. Biophys. Res. Commun. . 280 . 2 . 535–40 . January 2001 . 11162551 . 10.1006/bbrc.2000.4149 .
  4. Riley BE, Xu Y, Zoghbi HY, Orr HT . The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up . J. Biol. Chem. . 279 . 40 . 42290–301 . October 2004 . 15280365 . 10.1074/jbc.M406284200 . free .
  5. Marín I . The ubiquilin gene family: evolutionary patterns and functional insights . BMC Evol Biol . 14. 63 . March 2014 . 1 . 24674348 . 10.1186/1471-2148-14-63 . 4230246 . 2014BMCEE..14...63M . free .

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