UBE2V1 explained

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.^{[1] [2] [3]}

Function

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[3]

Interactions

UBE2V1 has been shown to interact with UBE2N.^[4]

Further reading

• Long M . A new function evolved from gene fusion. . Genome Res. . 10 . 11 . 1655–7 . 2001 . 11076848 . 10.1101/gr.165700 . free .
• Thomson TM, Khalid H, Lozano JJ, Sancho E, Ariño J . Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage. . FEBS Lett. . 423 . 1 . 49–52 . 1998 . 9580084 . 10.1016/S0014-5793(98)00060-X . 28536857 . 1998FEBSL.423...49T .
• Xiao W, Lin SL, Broomfield S, Chow BL, Wei YF . The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. . Nucleic Acids Res. . 26 . 17 . 3908–14 . 1998 . 9705497 . 147796 . 10.1093/nar/26.17.3908 .
• Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S . Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. . Oncogene . 17 . 10 . 1321–6 . 1998 . 9771976 . 10.1038/sj.onc.1202058 . 9281963 .
• Hofmann RM, Pickart CM . Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. . Cell . 96 . 5 . 645–53 . 1999 . 10089880 . 10.1016/S0092-8674(00)80575-9 . 17117789 . free .
• Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ . Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. . Cell . 103 . 2 . 351–61 . 2000 . 11057907 . 10.1016/S0092-8674(00)00126-4 . 18154645 . free .
• Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, Valeri M, Díaz VM, Abril J, Burset M, Merino J, Macaya A, Corominas M, Guigó R . Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. . Genome Res. . 10 . 11 . 1743–56 . 2001 . 11076860 . 310942 . 10.1101/gr.GR-1405R .
• Ito M, Shichijo S, Tsuda N, Ochi M, Harashima N, Saito N, Itoh K . Molecular basis of T cell-mediated recognition of pancreatic cancer cells. . Cancer Res. . 61 . 5 . 2038–46 . 2001 . 11280764 .
• Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W . Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. . J. Cell Biol. . 170 . 5 . 745–55 . 2005 . 16129784 . 2171356 . 10.1083/jcb.200502113 .
• Hau DD, Lewis MJ, Saltibus LF, Pastushok L, Xiao W, Spyracopoulos L . Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. . Biochemistry . 45 . 32 . 9866–77 . 2006 . 16893187 . 10.1021/bi060631r .
• Syed NA, Andersen PL, Warrington RC, Xiao W . Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. . Apoptosis . 11 . 12 . 2147–57 . 2007 . 17041755 . 10.1007/s10495-006-0197-3 . 6078250 .
• Petroski MD, Zhou X, Dong G, Daniel-Issakani S, Payan DG, Huang J . Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. . J. Biol. Chem. . 282 . 41 . 29936–45 . 2007 . 17709375 . 10.1074/jbc.M703911200 . free .

Notes and References

1. Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM . Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells . Mol Cell Biol . 18 . 1 . 576–89 . January 1998 . 9418904 . 121525 . 10.1128/mcb.18.1.576.
2. Rothofsky ML, Lin SL . CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter . Gene . 195 . 2 . 141–9 . October 1997 . 9305758 . 10.1016/S0378-1119(97)00097-8 .
3. Web site: Entrez Gene: UBE2V1 ubiquitin-conjugating enzyme E2 variant 1.
4. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ . Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain . Cell . 103 . 2 . 351–61 . October 2000 . 11057907 . 10.1016/S0092-8674(00)00126-4 . 18154645 . free .