UBE2O explained

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.^{[1] [2] [3]}

UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tomsig JL, Snyder SL, Creutz CE . Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. . J. Biol. Chem. . 278 . 12 . 10048–54 . 2003 . 12522145 . 10.1074/jbc.M212632200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 203–8 . 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .

Notes and References

1. Yokota T, Nagai H, Harada H, Mine N, Terada Y, Fujiwara H, Yabe A, Miyazaki K, Emi M . Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k . Gene . 267 . 1 . 95–100 . Apr 2001 . 11311559 . 10.1016/S0378-1119(01)00407-3 .
2. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 6 . 347–55 . Feb 2001 . 11214970 . 10.1093/dnares/7.6.347 . free .
3. Web site: Entrez Gene: UBE2O ubiquitin-conjugating enzyme E2O.
4. Nguyen AT, Prado MA, et al. . UBE2O remodels the proteome during terminal erythroid differentiation . Science . 357 . 6350 . eaan0218 . 2017 . 28774900 . 10.1126/science.aan0218. 5812729 .