UBE2H explained

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.^{[1] [2]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.^[3]

Further reading

• Wefes I, Mastrandrea LD, Haldeman M, etal . Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 11 . 4982–6 . 1995 . 7761435 . 10.1073/pnas.92.11.4982 . 41831 . 1995PNAS...92.4982W . free .
• Kaiser P, Mandl S, Schweiger M, Schneider R . Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. . FEBS Lett. . 377 . 2 . 193–6 . 1996 . 8543049 . 10.1016/0014-5793(95)01323-7 . 24431321 . free . 1995FEBSL.377..193K .
• Hayashida S, Yamasaki K, Asada Y, etal . Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. . Genomics . 66 . 2 . 221–5 . 2000 . 10860668 . 10.1006/geno.2000.6206 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . 19637860 . free .
• Vourc'h P, Martin I, Bonnet-Brilhault F, etal . Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. . Psychiatr. Genet. . 13 . 4 . 221–5 . 2005 . 14639049 . 10.1097/00041444-200312000-00005 . 25469223 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . 21903526 . free .
• Bartee E, Mansouri M, Hovey Nerenberg BT, etal . Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. . J. Virol. . 78 . 3 . 1109–20 . 2004 . 14722266 . 10.1128/JVI.78.3.1109-1120.2004 . 321412 .
• Chuang TH, Ulevitch RJ . Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. . Nat. Immunol. . 5 . 5 . 495–502 . 2004 . 15107846 . 10.1038/ni1066 . 39773935 .
• Kim HJ, Chong KH, Kang SW, etal . Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening. . Immunol. Lett. . 95 . 2 . 155–9 . 2005 . 15388255 . 10.1016/j.imlet.2004.07.001 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R . A human ubiquitin-conjugating enzyme homologous to yeast UBC8 . J Biol Chem . 269 . 12 . 8797–802 . Apr 1994 . 10.1016/S0021-9258(17)37039-4 . 8132613 . free .
2. Web site: Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast).
3. Web site: Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast).