UBE2G1 explained

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.^{[1] [2]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.^[3]

Further reading

• Chen P, Johnson P, Sommer T, etal . Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor . Cell . 74 . 2 . 357–69 . 1993 . 8393731 . 10.1016/0092-8674(93)90426-Q . 205020910 .
• Katsanis N, Fisher EM . Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene . Genomics . 51 . 1 . 128–31 . 1998 . 9693041 . 10.1006/geno.1998.5263 .
• Moynihan TP, Ardley HC, Nuber U, etal . The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1 . J. Biol. Chem. . 274 . 43 . 30963–8 . 1999 . 10521492 . 10.1074/jbc.274.43.30963 . free .
• Huang L, Kinnucan E, Wang G, etal . Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade . Science . 286 . 5443 . 1321–6 . 1999 . 10558980 . 10.1126/science.286.5443.1321 .
• Joazeiro CA, Hunter T . Biochemistry. Ubiquitination--more than two to tango . Science . 289 . 5487 . 2061–2 . 2000 . 11032556 . 10.1126/science.289.5487.2061 . 83324199 .
• Tiwari S, Weissman AM . Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s) . J. Biol. Chem. . 276 . 19 . 16193–200 . 2001 . 11278356 . 10.1074/jbc.M007640200 . free .
• Imai Y, Soda M, Inoue H, etal . An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin . Cell . 105 . 7 . 891–902 . 2001 . 11439185 . 10.1016/S0092-8674(01)00407-X . 721363 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Kim BW, Zavacki AM, Curcio-Morelli C, etal . Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2 . Mol. Endocrinol. . 17 . 12 . 2603–12 . 2004 . 12933904 . 10.1210/me.2003-0082 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Watanabe TK, Kawai A, Fujiwara T, Maekawa H, Hirai Y, Nakamura Y, Takahashi E . Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans . Cytogenet Cell Genet . 74 . 1–2 . 146–8 . Dec 1996 . 8893823 . 10.1159/000134403 .
2. Web site: Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast).
3. Web site: Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast).