UBE2C explained

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.^{[1] [2]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Further reading

• Fossey SC, Mychaleckyj JC, Pendleton JK, etal . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . 2001 . 11549316 . 10.1006/geno.2001.6584 .
• Tang Z, Li B, Bharadwaj R, etal . APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex . Mol. Biol. Cell . 12 . 12 . 3839–51 . 2002 . 11739784 . 10.1091/mbc.12.12.3839. 60759 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Lin Y, Hwang WC, Basavappa R . Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10 . J. Biol. Chem. . 277 . 24 . 21913–21 . 2002 . 11927573 . 10.1074/jbc.M109398200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Okamoto Y, Ozaki T, Miyazaki K, etal . UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme . Cancer Res. . 63 . 14 . 4167–73 . 2003 . 12874022 .
• Chuang TH, Ulevitch RJ . Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors . Nat. Immunol. . 5 . 5 . 495–502 . 2004 . 15107846 . 10.1038/ni1066 . 39773935 .
• Wagner KW, Sapinoso LM, El-Rifai W, etal . Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin . Oncogene . 23 . 39 . 6621–9 . 2004 . 15208666 . 10.1038/sj.onc.1207861 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Le XF, Lammayot A, Gold D, etal . Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling . J. Biol. Chem. . 280 . 3 . 2092–104 . 2005 . 15504738 . 10.1074/jbc.M403080200 . free .
• Pallante P, Berlingieri MT, Troncone G, etal . UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas . Br. J. Cancer . 93 . 4 . 464–71 . 2005 . 16106252 . 10.1038/sj.bjc.6602721 . 2361574 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Takahashi Y, Ishii Y, Nishida Y, etal . Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH . Cancer Genet. Cytogenet. . 168 . 1 . 30–5 . 2006 . 16772118 . 10.1016/j.cancergencyto.2005.12.011 .
• Lin J, Raoof DA, Wang Z, etal . Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma . Neoplasia . 8 . 12 . 1062–71 . 2007 . 17217624 . 10.1593/neo.05832 . 1783715 .
• Ieta K, Ojima E, Tanaka F, etal . Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression . Int. J. Cancer . 121 . 1 . 33–8 . 2007 . 17354233 . 10.1002/ijc.22605 . 12277353 . free .

Notes and References

1. Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV . Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase . Proc Natl Acad Sci U S A . 94 . 6 . 2362–7 . Apr 1997 . 9122200 . 20093 . 10.1073/pnas.94.6.2362 . 1997PNAS...94.2362T . free .
2. Web site: Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C.