U98 small nucleolar RNA explained

Small nucleolar RNA SNORA16B/SNORA16A family
Symbol:	SNORA16
Altsymbols:	U98
Rfam:	RF00190
Rna Type:	Gene snRNA; snoRNA; H/ACA-box
Tax Domain:	Eukaryota

U98 small nucleolar RNA also is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide" RNA.

U98 belongs to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines, the target for this family is unknown.^{[1] [2]} The mouse homologue was cloned and is called MBII-367.^[3]

Notes and References

1. Vitali P, Royo H, Seitz H, Bachellerie JP, Hüttenhofer A, Cavaillé J . Identification of 13 novel human modification guide RNAs . Nucleic Acids Research . 31 . 22 . 6543–51 . November 2003 . 14602913 . 275545 . 10.1093/nar/gkg849 .
2. Ganot P, Caizergues-Ferrer M, Kiss T . The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation . Genes & Development . 11 . 7 . 941–56 . April 1997 . 9106664 . 10.1101/gad.11.7.941 . free .
3. Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J . RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse . The EMBO Journal . 20 . 11 . 2943–53 . June 2001 . 11387227 . 125495 . 10.1093/emboj/20.11.2943 .