U7 small nuclear RNA explained

U7 small nuclear RNA
Symbol:U7
Rfam:RF00066
Rna Type:Gene
snRNA
Tax Domain:Eukaryota

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1] [2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3]

See also

Further reading

[4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] [49] [50] [51] [52] [53] [54] [55] [56] [57] [58] [59] [60] [61] [62] [63] [64] [65] [66] [67] [68] [69] [70] [71] [72] [73] [74] [75] [76] [77] [78] [79] [80] [81] [82] [83] [84]

External links

Notes and References

  1. Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D . 3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA . Nucleic Acids Res . 22 . 4023–4030 . 1994 . 7937126. 10.1093/nar/22.20.4023 . 20 . 331885.
  2. Mowry KL, Steitz JA . Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's . Science . 238 . 4834 . 1682–1687 . 1987 . 2825355. 10.1126/science.2825355. 1987Sci...238.1682M .
  3. Marzluff. William F.. Wagner. Eric J.. Duronio. Robert J.. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nature Reviews Genetics. 9. 11. 843–854. 10.1038/nrg2438. 2715827. 18927579. 2008.
  4. Voigt T, Meyer K, Baum O, Schümperli D . Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing . Neuromuscul Disord . 20 . 11 . 744–752 . 2010 . 20832308 . 10.1016/j.nmd.2010.06.010. 11835561 .
  5. Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D . The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs . Nucleic Acids Res . 38. 21. 7637–7650. 2010 . 20634199 . 2995043 . 10.1093/nar/gkq613.
  6. Geib T, Hertel KJ . Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs . PLOS ONE . 4 . 12 . e8204 . 2009 . 19997596 . 2781471 . 10.1371/journal.pone.0008204 . 2009PLoSO...4.8204G . Valcarcel . Juan. free .
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