| State: | ND |
| Type: | US |
| Route: | 52 |
| Map Custom: | yes |
| Map Notes: | US 52 highlighted in red |
| Length Mi: | 362.031 |
| Length Ref: | [1] |
| Established: | 1935 |
| Direction A: | West |
| Terminus A: | at the Canadian border in Portal |
| Junction: |
|
| Direction B: | East |
| Terminus B: | at the Minnesota state line in Fargo |
| Counties: | Burke, Renville, Ward, McHenry, Pierce, Sheridan, Wells, Foster, Stutsman, Barnes, Cass |
| Previous Type: | ND |
| Previous Route: | 50 |
| Next Type: | ND |
| Next Route: | 53 |
U.S. Highway 52 (US 52) is a 362adj=midNaNadj=mid United States Numbered Highway in the U.S. state of North Dakota, which travels from the Canada–United States border east to the Red River at Fargo. The highway connects the cities of Minot and Fargo and travels concurrent with Interstate 94 (I-94) between Jamestown and the Minnesota state line.
In North Dakota, US 52 continues from Saskatchewan Highway 39 from the Canada–United States border at North Portal, Saskatchewan and Portal, North Dakota to the Red River in Fargo, a distance of 361miles. US 52 passes through Burke, Ward, Renville, McHenry, Pierce, Sheridan, Wells, Foster, Stutsman, Barnes, and Cass counties.
US 52 is a two-lane highway in most areas, except for four lane segments between the Burlington area and Minot, Jamestown and Buchanan, and Jamestown and Fargo. Some segments in Fargo are six lanes.
From a point halfway between Foxholm and Burlington, and the southeast edge of Minot, US 52 is co-signed with US 2. As US 2/US 52 passes through the south part of Minot, it intersects with the US 83 Bypass, and then US 83 itself. Further south, US 52 is also co-signed with US 281 for 44miles between Carrington and Jamestown. The route through Jamestown follows 5th St. NW, 1st Ave., and I-94 Business Loop (the signs previously followed the eastern half, but now follow the shorter western half). From Jamestown east to the Minnesota border at Fargo, the highway is co-signed with Interstate 94.