| Type: | US |
| State: | CO |
| Route: | 350 |
| Map Custom: | yes |
| Map Notes: | US 350 highlighted in red |
| Length Mi: | 72.464 |
| Length Ref: | [1] |
| Spur Of: | 50 |
| Spur Type: | US |
| Direction A: | West |
| Terminus A: | near Trinidad |
| Direction B: | East |
| Terminus B: | in La Junta |
| Counties: | Las Animas, Otero |
| Previous Type: | CO |
| Previous Route: | 348 |
| Next Type: | CO |
| Next Route: | 368 |
U.S. Highway 350 (US 350) is a 73adj=midNaNadj=mid northeast–southwest United States highway located entirely within the state of Colorado.
US 350 starts at a junction with US 160 northeast of Trinidad. The highway runs northeast, past the Perry Stokes Airport and crossing the Purgatoire River. It then continues the rest of its length along a route chosen by the Atchison, Topeka and Santa Fe Railway, and close to the Mountain Branch of the Santa Fe Trail. The highway passes just northeast of the Piñon Canyon Maneuver Site, then crosses Comanche National Grassland before a junction with SH 71 going north.[2] At La Junta, the highway turns east on 5th Street, then north on Barnes Avenue before ending at a junction with US 50.
Until the 1990s, US 350 continued into Trinidad, where it intersected with Interstate 25 (I-25). Prior to the creation of I-25, the road terminated at US 85 and US 87.