| Post: | Ambassador |
| Body: | the United States to Uganda |
| Insignia: | Seal uganda mission.jpg |
| Insigniasize: | 120px |
| Insigniacaption: | Logo of the United States Mission to Uganda |
| Department: | United States Department of State |
| Incumbent: | William W. Popp |
| Incumbentsince: | September 20, 2023 |
| Style: | Mister Ambassador |
| Residence: | Kampala, Uganda |
| Nominator: | The President of the United States |
| Termlength: | At the Pleasure of The President |
| Inaugural: | Olcott Deming as Ambassador Extraordinary and Plenipotentiary |
| Formation: | January 7, 1963 |
| Website: | U.S. Embassy - Kampala |
The United States ambassador to Uganda is the official representative of the government of the United States to the Government of Uganda.
| Olcott Deming – Career FSO | Ambassador Extraordinary and Plenipotentiary | January 7, 1963 | January 14, 1963 | June 26, 1966 | |
| Henry Endicott Stebbins – Career FSO | June 27, 1966 | July 22, 1966 | September 2, 1969 | ||
| Clarence Clyde Ferguson, Jr. – Political appointee | March 17, 1970 | June 30, 1970 | July 19, 1972 | ||
| Thomas Patrick Melady – Political appointee | June 12, 1972 | July 30, 1972 | February 9, 1973 | ||
| David Crane Halsted – Career FSO | Chargé d'Affaires ad interim | June 18, 1979 | N/A | 1980 | |
| Gordon Robert Beyer[1] – Career FSO | Ambassador Extraordinary and Plenipotentiary | May 23, 1980 | June 13, 1980 | May 31, 1983 | |
| Allen Clayton Davis[2] – Career FSO | April 5, 1983 | July 1, 1983 | August 14, 1985 | ||
| Robert Gordon Houdek – Career FSO | October 28, 1985 | November 22, 1985 | August 17, 1988 | ||
| John A. Burroughs, Jr. – Political appointee | August 12, 1988 | November 4, 1988 | August 28, 1991 | ||
| Johnnie Carson – Career FSO | July 2, 1991 | September 18, 1991 | August 9, 1994 | ||
| E. Michael Southwick – Career FSO | August 26, 1994 | October 6, 1994 | August 1, 1997 | ||
| Nancy Jo Powell – Career FSO | November 7, 1997 | December 4, 1997 | July 9, 1999 | ||
| Martin George Brennan – Career FSO | August 9, 1999 | October 11, 1999 | July 5, 2002 | ||
| Jimmy J. Kolker – Career FSO | October 3, 2002 | November 17, 2002 | September 30, 2005 | ||
| Steven A. Browning[3] – Career FSO | February 21, 2005 | April 26, 2006 | July 5, 2009 | ||
| Jerry P. Lanier – Career FSO | August 10, 2009 | January 24, 2010 | June 11, 2012 | ||
| Scott H. DeLisi - Career FSO | June 30, 2012 | September 3, 2012 | September 18, 2015 | ||
| Deborah R. Malac – Career FSO | December 18, 2015 | February 27, 2016 | January 26, 2020 | ||
| Natalie E. Brown – Career FSO | August 6, 2020 | November 17, 2020 | August 30, 2023 | ||
| William W. Popp – Career FSO | July 27, 2023 | September 20, 2023 | Incumbent |