| Post: | Ambassador |
| Body: | the United States to Niger |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120 |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Kathleen A. FitzGibbon |
| Incumbentsince: | August 19, 2023 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | R. Borden Reams as Ambassador Extraordinary and Plenipotentiary |
| Formation: | October 14, 1960 |
| Website: | U.S. Embassy- Niamey |
The day before Niger's independence on August 3, 1960, the first American Chargé d'Affaires ad interim, Donald R. Norland, presented his credentials to take effect the following day. The first United States ambassador to Niger, R. Borden Reams was appointed on October 14, 1960 and presented his credentials on November 23.
| Donald R. Norland - Career FSO | Chargé d'Affaires ad interim | August 3, 1960 | N/A | October 14, 1960 | |
| R. Borden Reams - Career FSO | Ambassador Extraordinary and Plenipotentiary | October 14, 1960 | November 23, 1960 | August 2, 1961 | |
| Mercer Cook - Political appointee | June 22, 1961 | August 2, 1961 | May 30, 1964 | ||
| Robert J. Ryan - Career FSO | July 9, 1964 | August 24, 1964 | August 19, 1968 | ||
| Samuel C. Adams, Jr. - Political appointee[1] | July 24, 1968 | September 10, 1968 | October 3, 1969 | ||
| Roswell D. McClelland - Career FSO | July 8, 1970 | July 27, 1970 | July 7, 1973 | ||
| L. Douglas Heck - Career FSO | March 22, 1974 | May 30, 1974 | July 20, 1976 | ||
| Charles A. James - Political appointee | September 16, 1976 | December 11, 1976 | July 5, 1979 | ||
| James Keough Bishop - Career FSO | July 2, 1979 | September 1, 1979 | May 29, 1981 | ||
| William Robert Casey, Jr. - Political appointee | March 9, 1982 | April 3, 1982 | July 29, 1985 | ||
| Richard Wayne Bogosian - Career FSO | August 1, 1985 | October 11, 1985 | August 7, 1988 | ||
| Carl Copeland Cundiff - Career FSO | August 12, 1988 | September 9, 1988 | July 10, 1991 | ||
| Jennifer C. Ward - Career FSO | March 25, 1991 | August 16, 1991 | May 28, 1993 | ||
| John S. Davison - Career FSO | August 9, 1993 | October 23, 1993 | July 28, 1996 | ||
| Charles O. Cecil[2] - Career FSO | June 11, 1996 | September 6, 1996 | August 13, 1999 | ||
| Barbro Owens-Kirkpatrick - Career FSO | August 9, 1999 | October 11, 1999 | July 12, 2002 | ||
| Gail Dennise Thomas Mathieu - Career FSO | October 3, 2002 | December 4, 2002 | September 30, 2005 | ||
| Bernadette M. Allen - Career FSO | February 21, 2006 | April 19, 2006 | January 15, 2010 | ||
| Bisa Williams - Career FSO | August 9, 2010 | October 29, 2010 | September 13, 2013 | ||
| Eunice S. Reddick - Career FSO | June 30, 2014 | July 21, 2014 | January 25, 2018 | ||
| Eric P. Whitaker - Career FSO | November 2, 2017 | January 26, 2018 | December 1, 2021 | ||
| Susan N’Garnim - Career FSO | Chargé d'Affaires ad interim | December 1, 2021 | N/A | August 19, 2023 | |
| Kathleen A. FitzGibbon[3] - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 19, 2023 | N/A | Incumbent |