| Post: | Ambassador |
| Body: | the United States to Guinea-Bissau |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Michael A. Raynor |
| Incumbentsince: | April 20, 2022 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | Dean Curran as Chargé d'Affaires ad interim |
| Formation: | June 30, 1976 |
| Website: | U.S. Embassy - Dakar |
The United States ambassador to Guinea-Bissau is the official representative of the president of the United States to the head of state of Guinea-Bissau. The U.S. ambassador to Senegal is concurrently commissioned to Senegal and Guinea-Bissau.
Until 1974, Guinea-Bissau had been a colony of the Portuguese Empire as Portuguese Guinea. After a period of revolutionary warfare, Guinea-Bissau unilaterally declared its independence on September 24, 1973. Following the April 1974 Carnation Revolution in Portugal, it granted independence to Guinea-Bissau on September 10, 1974. The United States recognized the Republic of Guinea-Bissau on the same day. The U.S. Embassy Bissau was established on June 30, 1976, with Dean Curran as Chargé d'Affaires ad interim.[1]
The first three ambassadors to Guinea-Bissau were concurrently commissioned to Cape Verde while resident in Bissau. From 1983 until 1998, U.S. ambassadors were solely commissioned to Guinea-Bissau.[2] In 1998 the U.S. embassy in Bissau was closed,[3] and there has been no U.S. embassy in Bissau since then. Since 2002, the U.S. ambassador to Senegal has also been commissioned as the ambassador to Guinea-Bissau, while resident in Dakar.
| Melissa F. Wells[4] - Career FSO | Ambassador Extraordinary and Plenipotentiary | September 16, 1976 | November 29, 1976 | March 29, 1977 | |
| Edward Marks - Career FSO[5] | September 16, 1977 | October 31, 1977 | July 11, 1980 | ||
| Peter Jon de Vos - Career FSO | August 27, 1980 | September 22, 1980 | March 30, 1983 | ||
| Wesley Egan - Career FSO | March 18, 1983 | May 12, 1983 | January 7, 1985 | ||
| Barbara C. Maslak | Chargé d'Affaires ad interim | January 1985 | Unknown | August 1986 | |
| John Dale Blacken - Career FSO | Ambassador Extraordinary and Plenipotentiary | June 16, 1986 | August 27, 1986 | September 29, 1989 | |
| William Ludwig Jacobsen - Career FSO | October 10, 1989 | November 13, 1989 | August 25, 1992 | ||
| Roger A. McGuire - Career FSO | June 15, 1992 | October 14, 1992 | August 28, 1995 | ||
| Peggy Blackford - Career FSO | October 3, 1995 | November 4, 1995 | June 14, 1998 | ||
| Embassy suspended operations from 1998 to 2002. | |||||
| Richard Allan Roth[6] - Career FSO | Ambassador Extraordinary and Plenipotentiary | November 15, 2002 | February 13, 2004 | Left Dakar, August 4, 2005 | |
| Janice L. Jacobs - Career FSO | February 21, 2006 | May 9, 2006 | Left Dakar, July 15, 2007 | ||
| Marcia Bernicat - Career FSO | June 16, 2008 | November 6, 2008 | July 15, 2011 | ||
| Robert T. Yamate | Chargé d'Affaires ad interim | July 15, 2011 | Unknown | August 2011 | |
| Lewis A. Lukens – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 11, 2011 | October 19, 2011 | June 4, 2014 | |
| James P. Zumwalt – Career FSO | February 3, 2015 | March 10, 2015 | January 19, 2017 | ||
| Tulinabo S. Mushingi – Career FSO | May 19, 2017 | August 4, 2017 | February 1, 2022 | ||
| Michael A. Raynor – Career FSO | December 18, 2021 | April 20, 2022 | Incumbent | ||