| Post: | Ambassador |
| Body: | the United States to Cape Verde |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Jennifer M. Adams |
| Incumbentsince: | July 12, 2024 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | Melissa F. Wells as Ambassador Extraordinary and Plenipotentiary |
| Formation: | September 16, 1976 |
| Website: | U.S. Embassy - Praia |
Cape Verde had been a Portuguese colony for more than 500 years since 1456. In 1974 Portugal and the Cape Verdeans signed an agreement to form a transitional government, and Cape Verde gained full independence from Portugal on July 5, 1975.
The United States recognized Cape Verde and commissioned its first ambassador Melissa F. Wells in 1976. Ambassador Wells was concurrently accredited to Guinea-Bissau and Cape Verde while resident at Bissau, the capital of Guinea-Bissau. In 1980, an embassy was established in the capital Praia with a chargé d’affaires managing the business of the embassy. Until 1980 one ambassador, resident at Bissau, was concurrently commissioned to Guinea-Bissau and Cape Verde.
| Melissa F. Wells – Career FSO | Ambassador Extraordinary and Plenipotentiary | September 16, 1976 | November 18, 1976 | March 23, 1977 | |
| Edward Marks – Career FSO | September 15, 1977 | October 18, 1977 | July 11, 1980 | Embassy Praia was established January 28, 1978 with Howard McGowan as Chargé d’Affaires ad interim. The ambassador remained in Bissau. | |
| Peter Jon de Vos – Career FSO | September 5, 1980 | September 24, 1980 | Left Bissau, March 30, 1983 | In 1983 the first ambassador was appointed solely accredited to Cape Verde. | |
| John Melvin Yates – Career FSO | March 18, 1983 | April 26, 1983 | May 24, 1986 | ||
| Vernon Dubois Penner, Jr. – Career FSO | June 16, 1986 | July 15, 1986 | November 21, 1989 | ||
| Francis Terry McNamara – Career FSO | November 21, 1989 | December 23, 1989 | December 31, 1992 | ||
| Joseph Monroe Segars – Career FSO | July 14, 1992 | March 24, 1993 | March 17, 1996 | ||
| Lawrence Neal Benedict – Career FSO | June 6, 1996 | July 30, 1996 | August 11, 1999 | ||
| Michael D. Metelits – Career FSO | July 7, 1999 | September 15, 1999 | July 24, 2002 | ||
| Donald C. Johnson – Career FSO | October 3, 2002 | November 21, 2002 | April 4, 2005 | ||
| Roger D. Pierce – Career FSO | June 21, 2005 | September 27, 2005 | June 9, 2008 | ||
| Marianne M. Myles – Career FSO | June 6, 2008 | August 6, 2008 | August 1, 2011 | ||
| Dana Brown - Career FSO | Chargé d'Affaires ad interim | August 1, 2011 | Unknown | December 9, 2011 | |
| Adrienne S. O'Neal - Career FSO | Ambassador Extraordinary and Plenipotentiary | October 19, 2011 | December 9, 2011 | January 31, 2015 | |
| Donald Heflin - Career FSO | December 18, 2014 | January 31, 2015[1] | September 11, 2018 | ||
| John Jefferson Daigle - Career FSO | May 29, 2019 | September 10, 2019 | July 3, 2024 | ||
| Jennifer M. Adams - Career FSO | May 2, 2024 | July 12, 2024[2] | Incumbent |