U-92,016-A Explained

U-92,016-A is a psychoactive drug and research chemical used in scientific studies. It acts as a potent, high efficacy, and selective 5-HT1A receptor full agonist with a long duration of action.[1] [2] It has been suggested that it could be developed as an anxiolytic or antidepressant drug.

Notes and References

  1. 10.1021/jm00067a003 . Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F . Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. . J Med Chem . 36 . 15 . 2066–2074 . 1993 . 8101876 .
  2. McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, etal . Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. . J Pharmacol Exp Ther . 271 . 2 . 875–883 . 1994 . 7965808 .

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