Tyrosine ammonia-lyase explained

Tyrosine ammonia lyase
Ec Number:	4.3.1.23

Tyrosine ammonia lyase (EC 4.3.1.23, L-tyrosine ammonia-lyase, TAL or Tyrase) is an enzyme in the natural phenols biosynthesis pathway. It transforms L-tyrosine into p-coumaric acid.^{[1] [2] [3]}

 

\xrightarrow{TAL}   + Ammonia + H⁺L-tyrosine = trans-p-hydroxycinnamate + NH₃

See also

• EC 4.3.1.24 (phenylalanine ammonia-lyase)
• EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase)

External links

• • www.hhmi.org

Notes and References

1. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP . Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases . Chemistry & Biology . 13 . 12 . 1327–38 . December 2006 . 17185228 . 2859959 . 10.1016/j.chembiol.2006.11.011 .
2. Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C . Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family . Chemistry & Biology . 13 . 12 . 1317–26 . December 2006 . 17185227 . 10.1016/j.chembiol.2006.10.008 .
3. Schwede TF, Rétey J, Schulz GE . Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile . Biochemistry . 38 . 17 . 5355–61 . April 1999 . 10220322 . 10.1021/bi982929q .