Tyrosine-protein kinase Fes/Fps explained

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.^{[1] [2]} FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.^[3]

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.^[4]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1^[5] and BCR gene.^{[6] [7]}

Further reading

• Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N . The c-Fes family of protein-tyrosine kinases . Critical Reviews in Oncogenesis . 9 . 1 . 43–62 . 1998 . 9754447 . 10.1615/critrevoncog.v9.i1.40 .
• Jiang H, Harris MB, Rothman P . IL-4/IL-13 signaling beyond JAK/STAT . The Journal of Allergy and Clinical Immunology . 105 . 6 Pt 1 . 1063–70 . Jun 2000 . 10856136 . 10.1067/mai.2000.107604 . free .
• Greer P . Closing in on the biological functions of Fps/Fes and Fer . Nature Reviews Molecular Cell Biology . 3 . 4 . 278–89 . Apr 2002 . 11994747 . 10.1038/nrm783 . 22927394 .

Notes and References

1. Bowden DW, Akots G, Rothschild CB . An insertion deletion polymorphism associated with C-FES . Nucleic Acids Research . 19 . 15 . 4311 . Aug 1991 . 1870997 . 328602 . 10.1093/nar/19.15.4311 .
2. Web site: FES - Tyrosine-protein kinase Fes/Fps - Homo sapiens (Human) - FES gene & protein . www.uniprot.org . 16 May 2022 . en.
3. Craig AW . FES/FER kinase signaling in hematopoietic cells and leukemias . Frontiers in Bioscience . 17 . 22201778 . 2012 . 3 . 861–75 . 10.2741/3961. free .
4. Web site: Entrez Gene: FES feline sarcoma oncogene.
5. Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA . The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling . The Journal of Biological Chemistry . 272 . 4 . 2104–9 . Jan 1997 . 8999909 . 10.1074/jbc.272.4.2104 . free .
6. Lionberger JM, Smithgall TE . The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl . Cancer Research . 60 . 4 . 1097–103 . Feb 2000 . 10706130 .
7. Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE . Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS . Molecular and Cellular Biology . 15 . 2 . 835–42 . Feb 1995 . 7529874 . 231961 . 10.1128/MCB.15.2.835.