| Two Medicine River | |
| Map: | Mt-rivers.gif |
| Source1 Coordinates: | 48.4922°N -113.2636°W |
| Mouth Coordinates: | 48.4864°N -112.2278°W |
| Mouth Coord Ref: | [1] |
| Subdivision Type1: | Country |
| Subdivision Name1: | Pondera and Glacier County, Montana |
| Mouth Elevation: | 3294feet |
| Discharge1 Location: | Browning |
| Discharge1 Avg: | 375cuft/s[2] |
| River System: | Missouri River |
The Two Medicine River is a tributary of the Marias River, approximately 60 mi (97 km) long, in northwestern Montana in the United States.
It rises in the Rocky Mountain Front in Glacier National Park at the continental divide and flows east, down from the mountains and across the Blackfeet Indian Reservation. It receives Birch Creek in southeastern Glacier County and joins Cut Bank Creek to form the Marias, approximately 12 mi (19 km) southeast of Cut Bank.