| Twin Valley High School | |
| Streetaddress: | 100 Education Drive |
| City: | West Alexandria |
| State: | Ohio |
| County: | (Preble County) |
| Zipcode: | 45381 |
| Country: | USA |
| Coordinates: | 39.7472°N -84.5372°W |
| District: | Twin Valley Community Local Schools |
| Superintendent: | Scott Cottingim |
| Principal: | Doug Dunham |
| Type: | Public, Coeducational high school |
| Grades: | 9-12 |
| Conference: | Cross County Conference |
| Team Name: | Panthers[1] |
| Enrollment: | 256 (2016-17)[2] |
| Free Label3: | Athletic Director |
| Free Text3: | Braxston Campbell |
| Homepage: | http://www.tvs.k12.oh.us/ |
Twin Valley South High School is a public high school in West Alexandria, Ohio. It is the only high school in the Twin Valley Community Local School District. The school colors are scarlet and gray, and the mascot is the Panthers. Their main rival is Tri-County High School, located in Lewisburg, Ohio.
School sports include football, cross country, golf, boys and girls basketball, baseball, softball, volleyball, wrestling, co-ed track, and marching band.
* Title won by West Alexandria High School prior to consolidation into Twin Valley South.