| Official Name: | Twelvemile Corner, Illinois |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Illinois#USA |
| Pushpin Label: | Twelvemile Corner |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Illinois |
| Subdivision Type2: | County |
| Subdivision Name2: | Lee |
| Subdivision Type3: | Township |
| Subdivision Name3: | Viola |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 784 |
| Coordinates: | 41.7594°N -89.0833°W |
| Area Code: | 815 & 779 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 419969[1] |
Twelvemile Corner is an unincorporated community in Lee County, Illinois, United States. Twelvemile Corner is located at the intersection of U.S. Route 30 and Illinois Route 251, north of Compton.