Tubulointerstitial nephritis and uveitis explained

Synonyms:	Acute tubulointerstitial nephritis and uveitis syndrome
Tubulointerstitial nephritis and uveitis
Field:	ophthalmology

Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney).

Symptoms and signs

Uveitis may cause pain of the affected eye together with changes in vision. It may be accompanied by nonspecific systemic symptoms such as fever, involuntary weight loss, fatigue, loss of appetite, abdominal pain, and joint pains.^[1]

Laboratory diagnosisWe can see increased eosinophils under microscope after biopsy.

History

It was first described in 1975.^{[1] [2]}

References

1. Mackensen. F. Billing. H. Tubulointerstitial nephritis and uveitis syndrome.. Current Opinion in Ophthalmology. November 2009. 20. 6. 525–31. 10.1097/ICU.0b013e3283318f9a. 19752730. 11461472.
2. Dobrin. RS. Vernier. RL. Fish. AL. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome.. The American Journal of Medicine. September 1975. 59. 3. 325–33. 10.1016/0002-9343(75)90390-3. 1163543.