Tubular carcinoma explained

Tubular carcinoma is a subtype of invasive ductal carcinoma of the breast.^{[1] [2]} More rarely, tubular carcinomas may arise in the pancreas^[3] or kidney.^[4] Most tubular carcinomas begin in the milk duct of the breast and spread to healthy tissue around it.^{[5] [6]}

Pathology

Although tubular carcinoma has been considered a special-type tumor, recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS carcinomas with tubular features, depending on the percentage of the lesion that displays tubular features.

Histology

Tubular carcinomas are generally around 1 cm. or smaller, and are made up of tubules. They are usually low-grade. Elastosis has been noted as common but is not present in all cases.^[7]

Prevalence

Prevalence has previously been controversial, with contradictory reports from studies reporting either very low prevalence, or a high prevalence.^[8] With the increasing availability of screening mammography, however, tubular carcinomas are being diagnosed earlier, and more recent studies suggest tubular carcinomas represent between 8% and 27% of all breast cancers.

Prognosis

Tubular carcinoma is one of the histologic types of breast cancer with a more favorable outcome.^[9]

See also

• Breast cancer classification
• Ductal carcinoma in situ – a common precancerous or Stage 0 breast cancer
• Invasive cribriform carcinoma of the breast – a rare breast cancer that consists of >50% cribriform histopathology but commonly has small or large areas (<50%) closely resembling tubular carcinoma histopathology.^[10]
• Intraductal papillary mucinous neoplasm
• Invasive carcinoma of no special type
• Invasive lobular carcinoma
• Invasion (cancer)

Notes and references

Notes

References

Further reading

• Cserni . Gábor . Histological type and typing of breast carcinomas and the WHO classification changes over time . Pathologica . March 2020 . 112 . 1 . 25 - 41 . 10.32074/1591-951X-1-20 . 32202537 . 8138497.
• Erber . Ramona . Hartmann . Arndt . Histology of Luminal Breast Cancer . Breast Care . Basel . August 2020 . 15 . 4 . 327–336 . 10.1159/000509025 . 32982642. 7490665 .
• Book: Sanders . Melinda A. . Mayer . Ingrid A. . Chakravarthy . Bapsi . Derek . Raghavan . Manmeet S. . Ahluwalia . Charles D. . Blanke . Jubilee . Brown . Edward S. . Kim . Gregory H. . Reaman . Mikkael A. . Sekeres . 3 . 3 March 2017 . Textbook of Uncommon Cancer . 5 . John Wiley & Sons . 22 Tubular Carcinoma of the Breast . 338–344 . 978-1-119-19621-1 . 1069570078 . https://books.google.com/books?id=19lGDgAAQBAJ&pg=PA338 . .
• Zhang . Hanwen . Zhang . Ning . Special subtypes with favorable prognosis in breast cancer: A registry-based cohort study and network meta-analysis . Cancer Treatment Reviews . December 2020 . 91 . 102–108 . 10.1016/j.ctrv.2020.102108 . 33075683 .

Notes and References

1. Web site: Hudis . Kenneth . IDC Type: Tubular Carcinoma of the Breast . 22 June 2019 . Breastcancer.org . 26 February 2022.
2. Limaiem . Faten . Mlika . Mouna . Tubular Breast Carcinoma . StatPearls . 2022 . 3 March 2022 . StatPearls Publishing. 31194380 .
3. Chelliah . Adeline . Kalimuthu . Sangeetha . Chetty . Runjan . Intraductal tubular neoplasms of the pancreas: an overview . Ann Diagn Pathol . October 2016 . 24 . 24:68–72 . 68–72 . 10.1016/j.anndiagpath.2016.04.009 . 27185640 .
4. Zhao . Ming . He . Xiang-lei . Teng . Xiao-dong . Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects . Diagnostic Pathology . December 2015 . 10 . 1 . 168 . 10.1186/s13000-015-0402-1. 26377921 . 4573286 . free .
5. Book: Musser, Robert . 2009 . The P.I.N.K. Primer . Dog Ear Publishing . 20– . 978-1-60844-176-1 .
6. Feng . Yixiao . Spezia . Mia . Huang . Shifeng . Yuan . Chengfu . Zeng . Zongyue . Zhang . Linghuan . Ji . Xiaojuan . Liu . Wei . Huang . Bo . Luo . Wenping . Liu . Bo . Lei . Yan . Du . Scott . Vuppalapati . Akhila . Luu . Hue H. . Haydon . Rex C. . He . Tong-Chuan . Ren . Guosheng . Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis . Genes & Diseases . June 2018 . 5 . 2 . 77–106 . 10.1016/j.gendis.2018.05.001 . 30258937 . 6147049 . en.
7. Book: Rosen . Paul Peter . 2001 . Rosen's Breast Pathology . Lippincott Williams & Wilkins . 373– . 978-0-7817-2379-4 . 1117861419 .
8. Book: Stavros, A. Thomas . Rapp . Cynthia L. . Parker . Steve H. . 2004 . Breast Ultrasound . Lippincott Williams & Wilkins . 647–649 . 978-0-397-51624-7 . 1065689596 . A highly differentiated invasive carcinoma that forms well-defined tubules (containing epithelium, but no myoepithelium) and that have abundant desmoplastic fibrous stromal reaction between the tubules. . 649.
9. Web site: Breast Cancer Treatment (Adult) (PDQ®)–Health Professional Version . 20 January 2022 . . 26 February 2022.
10. Demir S, Sezgin G, Sari AA, Kucukzeybek BB, Yigit S, Etit D, Yazici A, Kucukzeybek Y . Clinicopathological analysis of invasive cribriform carcinoma of the breast, with review of the literature . Annals of Diagnostic Pathology . 54 . 151794 . October 2021 . 34325338 . 10.1016/j.anndiagpath.2021.151794 .