Troxerutin Explained

Troxerutin is a flavonol, a type of flavonoid, derived from rutin.^[1] It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree.

It is used as a vasoprotective.^[2]

Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet.^[3]

Notes and References

1. Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B . Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice . Biochemical Pharmacology . 91 . 1 . 74–86 . September 2014 . 25026599 . 10.1016/j.bcp.2014.07.002 .
2. Riccioni C, Sarcinella R, Izzo A, Palermo G, Liguori M . [Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency] . Minerva Cardioangiologica . 52 . 1 . 43–8 . February 2004 . 14765037 .
3. Lu J, Wu DM, Zheng ZH, Zheng YL, Hu B, Zhang ZF . Troxerutin protects against high cholesterol-induced cognitive deficits in mice . Brain . 134 . Pt 3 . 783–97 . March 2011 . 21252113 . 10.1093/brain/awq376 . free .