Tropomodulin 2 Explained
Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.[1]
Function
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[2]
Further reading
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Pawlak G, McGarvey TW, Nguyen TB, etal . Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder. . Int. J. Cancer . 110 . 3 . 368–73 . 2004 . 15095301 . 10.1002/ijc.20151 . 875146 .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
- Watakabe A, Kobayashi R, Helfman DM . N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. . J. Cell Sci. . 109 . 9. 2299–310 . 1996 . 10.1242/jcs.109.9.2299 . 8886980 .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
Notes and References
- Huda Zoghbi . Cox PR, Zoghbi HY . Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs . Genomics . 63 . 1 . 97–107 . January 2000 . 10662549 . 10.1006/geno.1999.6061 .
- Web site: Entrez Gene: TMOD2, Tropomodulin 2 (neuronal).