Tropomodulin 1 Explained

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.^{[1] [2] [3]}

Further reading

• Ursitti JA, Fowler VM . Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons. . J. Cell Sci. . 107 . 6. 1633–9 . 1994 . 10.1242/jcs.107.6.1633 . 7962203 .
• Sung LA, Lin JJ . Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene. . Biochem. Biophys. Res. Commun. . 201 . 2 . 627–34 . 1994 . 8002995 . 10.1006/bbrc.1994.1747 .
• Sussman MA . Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions . Exp. Cell Res. . 209 . 2 . 388–91 . 1994 . 8262158 . 10.1006/excr.1993.1325 . vanc. Bilak M . Kedes L . 3 . Engel . WK . Askanas . V .
• Lench NJ . An EST and STS-based YAC contig map of human chromosome 9q22.3 . Genomics . 38 . 2 . 199–205 . 1997 . 8954802 . 10.1006/geno.1996.0616 . vanc. Telford EA . Andersen SE . 3 . Moynihan . TP . Robinson . PA . Markham . AF .
• Vera C . Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5 . Arch. Biochem. Biophys. . 378 . 1 . 16–24 . 2000 . 10871039 . 10.1006/abbi.2000.1802 . vanc. Sood A . Gao KM . 3 . Yee . LJ . Lin . JJ . Sung . LA .
• McElhinny AS . The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments . J. Biol. Chem. . 276 . 1 . 583–92 . 2001 . 11016930 . 10.1074/jbc.M005693200 . vanc. Kolmerer B . Fowler VM . 3 . Labeit . S . Gregorio . CC . free .
• Chu X, Thompson D, Yee LJ, Sung LA . Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments . Gene . 256 . 1–2 . 271–81 . 2001 . 11054557 . 10.1016/S0378-1119(00)00327-9 .
• Greenfield NJ, Fowler VM . Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin . Biophys. J. . 82 . 5 . 2580–91 . 2002 . 11964245 . 10.1016/S0006-3495(02)75600-2 . 1302047 . 2002BpJ....82.2580G .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Rho SB . The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture . FEBS Lett. . 557 . 1–3 . 57–63 . 2004 . 14741341 . 10.1016/S0014-5793(03)01438-8 . vanc. Chun T . Lee SH . 3 . Park . Kyoungsook . Lee . Je-Ho . 84342157 . free.
• Pawlak G . Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder . Int. J. Cancer . 110 . 3 . 368–73 . 2004 . 15095301 . 10.1002/ijc.20151 . vanc. McGarvey TW . Nguyen TB . 3 . Tomaszewski . John E. . Puthiyaveettil . Raghunath . Malkowicz . S. Bruce . Helfman . David M. . 875146 .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . vanc. Oliver K . Hunt AR . 3 . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Vera C, Lao J, Hamelberg D, Sung LA . Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction . Arch. Biochem. Biophys. . 444 . 2 . 130–8 . 2006 . 16297372 . 10.1016/j.abb.2005.10.002 .
• Kong KY, Kedes L . Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres . J. Biol. Chem. . 281 . 14 . 9589–99 . 2006 . 16434395 . 10.1074/jbc.M512064200 . free .

Notes and References

1. Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S . Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein . J Biol Chem . 267 . 4 . 2616–21 . Mar 1992 . 10.1016/S0021-9258(18)45926-1 . 1370827 . free .
2. Sung LA, Fan Y, Lin CC . Gene assignment, expression, and homology of human tropomodulin . Genomics . 34 . 1 . 92–6 . Dec 1996 . 8661028 . 10.1006/geno.1996.0245 .
3. Web site: Entrez Gene: TMOD1 tropomodulin 1.