Tropanserin Explained

Tropanserin (INN; MDL-72,422) is a drug which acts as a potent and selective 5-HT₃ receptor antagonist.^[1] It was investigated in clinical trials for the treatment of migraine in the 1980s but was never marketed.^[2]

Synthesis

Tropanserin can be prepared by the reaction of tropine with 3,5-dimethylbenzoyl chloride.

See also

• Bemesetron
• Zatosetron
• Ricasetron
• Granisetron
• Tropisetron

Notes and References

1. Book: King FD, Jones BJ, Sanger GJ . 5-Hydroxytryptamine-3 Receptor Antagonists . 6 May 2012 . 22 October 1993 . CRC Press . 978-0-8493-5463-2 . 244.
2. Book: Johnson G . Recent Advances in Migraine Research . Bailey DM . Annual Reports in Medicinal Chemistry . https://books.google.com/books?id=oJeTSJveeuAC&pg=PA44 . 1 August 1987 . 22 . Academic Press . 978-0-08-058366-2 . 10.1016/S0065-7743(08)61153-7 . 44.