Troleandomycin Explained

Troleandomycin (TAO for short[1]) is a macrolide antibiotic. It was sold in Italy (branded Triocetin) and Turkey (branded Tekmisin). It is no longer sold in Italy as of 2018.

The drug's mode of action is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis.[2] Troleandomycin is a CYP3A4 inhibitor that may cause drug interactions.

Notes and References

  1. Zeiger RS, Schatz M, Sperling W, Simon RA, Stevenson DD . Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma . The Journal of Allergy and Clinical Immunology . 66 . 6 . 438–46 . December 1980 . 6968762 . 10.1016/0091-6749(80)90003-2 . free .
  2. Gürel G, Blaha G, Steitz TA, Moore PB . Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui . Antimicrobial Agents and Chemotherapy . 53 . 12 . 5010–4 . December 2009 . 19738021 . 2786347 . 10.1128/AAC.00817-09 .

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