| Trofeo Pantalica | |
| Date: | Early March |
| Region: | Province of Syracuse, Italy |
| English: | Trophy Pantalica |
| Localnames: | Trofeo Pantalica |
| Discipline: | Road |
| Competition: | UCI Europe Tour |
| Type: | Single-day |
| Organiser: | RCS Sport |
| Number: | 28 |
| Last: | 2003 |
| Mostwins: | (5 wins) |
The Trofeo Pantalica was a professional road bicycle race held annually in Province of Syracuse, Italy. The last edition took place in 2003.