| Tripoli Creek | |
| Name Other: | French: ruisseau Tripoli |
| Pushpin Map: | Canada Ontario |
| Pushpin Map Caption: | Location of the mouth of Tripoli Creek in Ontario |
| Subdivision Type1: | Country |
| Subdivision Name1: | Canada |
| Subdivision Type2: | Province |
| Subdivision Name2: | Ontario |
| Subdivision Type3: | Region |
| Subdivision Name3: | Northeastern Ontario |
| Subdivision Type4: | District |
| Subdivision Name4: | Algoma |
| Subdivision Type5: | Part |
| Subdivision Name5: | Unorganized North |
| Source1: | West Tripoli Lake |
| Source1 Coordinates: | 48.4683°N -84.8297°W |
| Source1 Elevation: | 424m (1,391feet) |
| Mouth: | Esnagi Lake |
| Mouth Coordinates: | 48.5661°N -84.6061°W |
| Mouth Elevation: | 347m (1,138feet) |
| River System: | Lake Superior drainage basin |
| Tributaries Right: | Ryerson Creek |
Tripoli Creek (French: ruisseau Tripoli) is a creek in the Unorganized North Part of Algoma District in northeastern Ontario, Canada. It is part of the Lake Superior drainage basin.
The creek begins at West Tripoli Lake at an elevation of . It heads northeast under the Canadian Pacific Railway transcontinental mainline between the settlements of Amyot to the west and the Girdwood railroad flag stop, 1.6km (01miles) to the east, to reach Tripoli Lake. Tripoli Creek continues northeast, takes in the right tributary Ryerson Creek, and reaches its mouth at Esnagi Lake on the Magpie River at an elevation of 347m (1,138feet).