Lamivudine/nevirapine/stavudine explained
| Type: | combo |
| Component1: | Lamivudine |
| Class1: | nucleoside reverse transcriptase inhibitor |
| Component2: | Nevirapine |
| Class2: | non-nucleoside reverse transcriptase inhibitor |
| Component3: | Stavudine |
| Class3: | nucleoside reverse transcriptase inhibitor |
| Tradename: | Triomune, others |
| Cas Number: | 811471-91-7 |
| Atc Prefix: | J05 |
| Atc Suffix: | AR07 |
| Chemspiderid: | none |
Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains lamivudine, nevirapine, and stavudine. It is either used by itself or along with other antiretrovirals. It is taken by mouth twice a day.[1]
It is on the World Health Organization's List of Essential Medicines.[2] As of 2015, it is not commercially available in the United States.[3]
Medical uses
It is a common first line treatment in the developing world.[4]
Adverse effects and safety
The medication is generally well tolerated. Side effects are those of the underlying medications.[1] This may include rash, numbness, pancreatitis, and high blood lactate levels. Use is not recommended in those with significant liver problems. It is unclear if use in pregnancy is safe for the baby and recommendations include starting in the second trimester if possible.[5]
External links
Notes and References
- Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . ((World Health Organization)) . Stuart MC, Kouimtzi M, Hill SR . 10665/44053 . World Health Organization . World Health Organization . free . 160 .
- Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . free .
- Book: Kasper DL, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J . Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2). 2015. McGraw Hill Professional . 9780071802161 . 1277 . en . live . https://web.archive.org/web/20161220163724/https://books.google.ca/books?id=wNKVBgAAQBAJ . 2016-12-20.
- Siegfried NL, Van Deventer PJ, Mahomed FA, Rutherford GW . Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults . The Cochrane Database of Systematic Reviews . 2006 . 2 . CD004535 . April 2006 . 16625606 . 8407055 . 10.1002/14651858.CD004535.pub2 .
- Web site: Nevirapine/stavudine/lamivudine. aidsmap. 18 December 2016. dead. https://web.archive.org/web/20161220154753/http://www.aidsmap.com/files/file1000082.pdf. 20 December 2016.
