Trimerelysin II explained

Trimerelysin II
Ec Number:3.4.24.53
Cas Number:151125-15-4

Trimerelysin II (Trimeresurus metalloendopeptidase II, proteinase H2, H2-proteinase) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, His10-Leu and Ala14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

Notes and References

  1. Takahashi T, Ohsaka A . Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity . Biochimica et Biophysica Acta (BBA) - Enzymology . 198 . 2 . 293–307 . February 1970 . 4984550 . 10.1016/0005-2744(70)90062-8 .
  2. Takeya H, Arakawa M, Miyata T, Iwanaga S, Omori-Satoh T . Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis . Journal of Biochemistry . 106 . 1 . 151–7 . July 1989 . 10.1093/oxfordjournals.jbchem.a122805 . 2777746 .

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