Trichosanthin Explained

Altnames:	α-Trichosanthin
Width:	200
Cas Number:	60318-52-7
Uniprot:	P09989

Trichosanthin is a ribosome-inactivating protein.^{[1] [2]} It is derived from Trichosanthes kirilowii.^[3] It is also an abortifacient.^[4]

Notes and References

1. Too PH, Ma MK, Mak AN, etal . The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome . Nucleic Acids Res. . 37 . 2 . 602–10 . February 2009 . 19073700 . 10.1093/nar/gkn922 . 2632931.
2. Shaw PC, Lee KM, Wong KB . Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties . Toxicon . 45 . 6 . 683–9 . May 2005 . 15804517 . 10.1016/j.toxicon.2004.12.024 .
3. Zhao J, Ben LH, Wu YL, etal . Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors . J. Exp. Med. . 190 . 1 . 101–11 . July 1999 . 10429674 . 2195565 . 10.1084/jem.190.1.101.
4. Li MX, Yeung HW, Pan LP, Chan SI. Sunney Chan . Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro . Nucleic Acids Res. . 19 . 22 . 6309–12 . November 1991 . 1659689 . 329144 . 10.1093/nar/19.22.6309.