Trichodiene synthase explained

trichodiene synthase
Ec Number:4.2.3.6
Cas Number:101915-76-8
Go Code:0045482

The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate

\rightleftharpoons

trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,, and .

References