Tricetin Explained

Tricetin is a flavone, a type of flavonoid. It is a rare aglycone found in the pollen of members of the Myrtaceae, subfamily Leptospermoideae, such as Eucalyptus globulus.^[1] This compound shows anticancer effects on human breast adenocarcinoma MCF-7 cells.^[2] Moreover. a potent anti-inflammatory effect of tricetin has also been demonstrated in a model of acute pancreatitis.^[3] This observation was explained by the compound's radical scavenging effects, its inhibitory effect on the DNA damage sensor enzyme poly (ADP-ribose) polymerase-1 (PARP1) and PARP1-mediated cell death and suppression of inflammatory gene expression.

See also

• Tricin synthase produces tricin or tricetin 3′,5′-dimethyl ether
• Tricetin 3′,4′,5′-O-trimethyltransferase

Notes and References

1. Campos . Maria G. . Webby . Rosemary F. . Markham . Kenneth R. . 2002 . The unique occurrence of the flavone aglycone tricetin in Myrtaceae pollen . Zeitschrift für Naturforschung C . 57 . 9–10 . 944–946 . 10.1515/znc-2002-9-1031 . free . 12440738 . 29128828 . free.
2. Hsu . Ya-Ling . Uen . Yih-Huei . Chen . Yi . Liang . Hsin-Lin . Kuo . Po-Lin . 2009 . Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma MCF-7 cells by blocking cell cycle progression and inducing apoptosis . Journal of Agricultural and Food Chemistry . 57 . 18 . 8688–8695 . 10.1021/jf901053x . 19705844 . 19856762.
3. Nagy-Pénzes . Máté . Hajnády . Zoltán . Regdon . Zsolt . Demény . Máté Á . Kovács . Katalin . El-Hamoly . Tarek . Maléth . József . Hegyi . Péter . Hegedűs . Csaba . Virág . László . June 2022 . Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling . Biomedicines . en . 10 . 6 . 1371 . 10.3390/biomedicines10061371 . 35740393 . 9219693 . 2227-9059. free .