Triazolopyridine Explained

Triazolopyridines are a class of heterocyclic chemical compounds with a triazole ring fused to a pyridine ring. There are multiple isomers which differ by the location of the nitrogen atoms and the nature of the ring fusion.

The term triazolopyridine can also refer to a class of antidepressant drugs whose chemical structure includes a trazolopyridine-derived ring system.[1] One example is trazodone.[2]

Other pharmaceutical drugs that contain a triazolopyridine ring system include filgotinib, tucatinib, and enarodustat. In addition, the reagents used in organic chemistry HATU, HOAt, and PyAOP[3] are triazolopyridine derivatives.

Notes and References

  1. Web site: Triazolopyridine antidepressant . dictionary.com .
  2. 6993447 . J Clin Psychiatry . 1980 . 41 . 7 . 250-255 . Trazodone, a triazolopyridine derivative, in primary depressive disorder . J P Feighner .
  3. 10.1002/047084289X.rn00199 . (7-Azabenzotriazol-1-yloxy)tris(pyrrolidino)phosphonium Hexafluorophosphate . Jacques Coste, Patrick Jouin . April 15, 2003 . Encyclopedia of Reagents for Organic Synthesis .