| Trepuzzi | |
| Official Name: | Comune di Trepuzzi |
| Shield Alt: | Coat of arms |
| Pushpin Label Position: | left |
| Coordinates: | 40.4°N 22°W |
| Region: | Apulia |
| Province: | (LE) |
| Mayor: | Giuseppe Taurino |
| Area Total Km2: | 23.43 |
| Population Footnotes: | [1] |
| Population Total: | 14757 |
| Population As Of: | 31 December 2014 |
| Population Demonym: | Trepuzzini |
| Elevation M: | 55 |
| Saint: | Assumption of Mary |
| Day: | 15 August |
| Postal Code: | 73019 |
| Area Code: | 0832 |
Trepuzzi (Salentino: Sicilian: Trepuzze) is a town and comune in the province of Lecce in the Apulia region of south-east Italy.