Trendione Explained

Trendione (developmental code name RU-2065; nickname Trenavar), also known as estra-4,9,11-triene-3,17-dione, is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone.^{[1] [2] [3] [4] [5]} Trendione is to trenbolone as androstenedione is to testosterone.^[6] The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone.^{[7] [8]} It is a designer steroid and has been sold on the internet as a "nutritional supplement". Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014.

See also

• List of androgens/anabolic steroids

Notes and References

1. Liane BJ, Magee C . Guerilla Warfare on the Pancreas? A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic-Androgenic Steroids . Mil Med . 181 . 10 . e1395–e1397 . October 2016 . 27753588 . 10.7205/MILMED-D-15-00575 . free .
2. Yarrow JF, McCoy SC, Borst SE . Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity . Steroids . 75 . 6 . 377–89 . June 2010 . 20138077 . 10.1016/j.steroids.2010.01.019 . 205253265 .
3. Metzler M . Metabolism of some anabolic agents: toxicological and analytical aspects . J. Chromatogr. . 489 . 1 . 11–21 . April 1989 . 2745641 . 10.1016/s0378-4347(00)82880-7.
4. Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE . 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate . Am. J. Physiol. Endocrinol. Metab. . 300 . 4 . E650–60 . April 2011 . 21266670 . 10.1152/ajpendo.00440.2010 . 6189634 .
5. Spranger B, Metzler M . Disposition of 17 beta-trenbolone in humans . J. Chromatogr. . 564 . 2 . 485–92 . April 1991 . 1874853 . 10.1016/0378-4347(91)80517-g.
6. Book: Advances in Agronomy. 13 April 2007. Elsevier. 978-0-08-048819-6. 16–.
7. Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH . Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor . APMIS . 108 . 12 . 838–46 . December 2000 . 11252818 . 10.1111/j.1600-0463.2000.tb00007.x. 22776408 .
8. Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP . Steroid flexibility and receptor specificity . J. Steroid Biochem. . 13 . 1 . 45–59 . January 1980 . 7382482 . 10.1016/0022-4731(80)90112-0 .