Tremorine Explained

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.^{[1] [2] [3] [4] [5]} Beta blockers are also effective in counteracting the effects of tremorine.^[6]

History

Tremorine was first reported by Everett et al. in 1956-57.^{[7] [8] [9] [10]}

See also

• Oxotremorine

Notes and References

1. Trautner EM, Gershon S . Use of tremorine for screening anti-parkinsonian drugs . Nature . 183 . 4673 . 1462–3 . May 1959 . 13657170 . 10.1038/1831462a0 . 1959Natur.183.1462T . 4173699 .
2. Friedman AH, Aylesworth RJ, Friedman G . Tremorine: Its Effect on Amines of the Central Nervous System . Science . 141 . 3586 . 1188–90 . September 1963 . 14043364 . 10.1126/science.141.3586.1188 . 1963Sci...141.1188F . 37472968 .
3. Menon M, Clark WG, Aures D . 10.1016/0031-6989(71)90005-1 . Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats . Pharmacological Research Communications . 3 . 4 . 345–350 . 1971 .
4. Shinozaki H, Hirate K, Ishida M . Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency . Experimental Neurology . 88 . 2 . 303–15 . May 1985 . 3987859 . 10.1016/0014-4886(85)90193-1 . 7607662 .
5. Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN . Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology . Pharmacology, Biochemistry, and Behavior . 79 . 4 . 745–9 . December 2004 . 15582683 . 10.1016/j.pbb.2004.10.004 . 28371865 .
6. Paul V . The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists . Indian Journal of Physiology and Pharmacology . 30 . 4 . 307–12 . 1986 . 2883120 .
7. Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousandcompounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
8. Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
9. Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
10. Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.