Transportin-3 Explained

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.^{[1] [2] [3]}

Function

TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.^{[1] [3]}

Clinical significance

The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lai MC, Lin RI, Tarn WY . Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 18 . 10154–9 . 2001 . 11517331 . 10.1073/pnas.181354098 . 56931 . free .
• Allemand E, Dokudovskaya S, Bordonné R, Tazi J . A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1. . Mol. Biol. Cell . 13 . 7 . 2436–47 . 2003 . 12134081 . 10.1091/mbc.E02-02-0102 . 117325 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tsang HT, Connell JW, Brown SE, etal . A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. . Genomics . 88 . 3 . 333–46 . 2006 . 16730941 . 10.1016/j.ygeno.2006.04.003 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Kataoka N, Bachorik JL, Dreyfuss G . Transportin-SR, a nuclear import receptor for SR proteins . J Cell Biol . 145 . 6 . 1145–52 . Jul 1999 . 10366588 . 2133142 . 10.1083/jcb.145.6.1145 .
2. Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY . A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins . J Biol Chem . 275 . 11 . 7950–7 . Apr 2000 . 10713112 . 10.1074/jbc.275.11.7950 . free .
3. Web site: Entrez Gene: TNPO3 transportin 3.
4. Radstake TR, Gorlova O, Rueda B, etal . Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus . Nat. Genet. . 42 . 5 . 426–9 . May 2010 . 20383147 . 10.1038/ng.565 . 2861917.